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Green synthesis of selenium nanoparticles within honey and evaluation of their cytotoxicity effects

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Writers: Hamed Amiri Farmad, Seyed Isaac Hashemy, Majid Darroudi

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Tag: Nanomedicine

Code: GP-30625

Abstract: Over recent years, selenium nanoparticles (Se-NPs) have been widely applied in nanomedicine science due to their....

Over recent years, selenium nanoparticles (Se-NPs) have been widely applied in nanomedicine science due to their exceptional biological properties. The available reports regarding the fabrication methods of these nanoparticles mainly include physical and chemical processes that are toxic, costly, and non-environmental friendly. In this study, Se-NPs were synthesized through a rapid, biocompatible, and green chemistry approach with the usage of bioactive compounds of honey. Se-NPs@Honey were characterized by UV–Vis, TEM, and XRD techniques. Firstly, UV–Vis spectrum revealed a strong peak at 283 nm which could be associated with the surface plasmon resonance (SPR) of Se-NPs@Honey. TEM image indicated the spherical shape of the bio-synthesized Se-NPs@Honey with an average particle size about 50 nm. Additionally, in vitro toxicity of Se-NPs@Honey was examined on A2780 ovarian cancer cells using resazurin-based cytotoxicity assay. Interestingly, Se-NPs@Honey showed the time and concentration-dependent anti-proliferative activity towards ovarian cancer cells.


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