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نویسندگان: Saman Emami Gerami, Hooman Fatoorehchi, Fatemeh Yazdian, Hamid Rashedi

زمان بندی: بدون زمان بندی

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برچسب: Nanomedicine

کد: GP-98431

خلاصه مقاله: Chitosan (CS)/polyvinylpyrrolidone (PVP)/hematite (-Fe2O3) nanocomposites loaded with Doxorubicin (drug model) were....

Chitosan (CS)/polyvinylpyrrolidone (PVP)/hematite (-Fe2O3) nanocomposites loaded with Doxorubicin (drug model) were synthesized via an oil-in-water emulsification method to develop a biocompatible and pH-sensitive drug nanocarrier for the first time. A hydrogel, including CS, PVP, and -Fe2O3, was fabricated successfully with glutaraldehyde (GA) as the cross-linker. Incorporating -Fe2O3 into CS/PVP hydrogel improved the pH-sensitivity and developed beneficial hydrogel. FTIR analysis illustrated chemical bonding in nanocomposite's structure. Besides, the in vitro cytotoxicity was studied to recognize biological properties which revealed that drug-loaded nanocomposite caused high inhibition to MCF-7 cells in presence of -Fe2O3. By and large, this study confirmed CS/PVP/-Fe2O3 nanocomposites as a potential candidate for the controlled pH-sensitive release of the drug.


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