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نویسندگان: Houra Nekounam, Narges Mahmoodi, Elham Hasanzadeh, Reza Faridi Majidi

زمان بندی: بدون زمان بندی

یونیت نمایش:

برچسب: Nanomedicine

کد: GP-05429

خلاصه مقاله: Abstract : The application of electroactive scaffolds can be promising for bone tissue engineering applications. In the....

Abstract : The application of electroactive scaffolds can be promising for bone tissue engineering applications. In the current paper, we aimed to fabricate an electro-conductive scaffold based on carbon nanofibers (CNFs) composited with Fe2O3 nanoparticles. FeSO4·7H2O salt with different concentrations 5, 10, and 15 wt%, were blended with polyacrylonitrile (PAN) polymer as the precursor and converted to Fe2O3/CNFs nanocomposite by electrospinning and heat treatment. The characterization was conducted using SEM, EDX, XRD, FTIR, and Raman methods. The results showed that the incorporation of Fe salt did not induce an adverse effect on the nanofibers' morphology. The average diameter of CNFs fabricated from PAN containing 5, 10, and 15 wt.% ferrous sulfates were 102, 126, and 138 nm, respectively. EDX analysis confirmed that the Fe NPs are uniformly dispersed throughout the CNF mat. FTIR spectroscopy showed the interaction of Fe salt with PAN polymer. Raman spectroscopy showed that the incorporation of FeSO4·7H2O reduced the ID/IG ratio, indicating more ordered carbon in the synthesized nanocomposite. Electrical resistance measurement depicted that the incorporation of ferrous sulfate reduced the electrical conductivity. The in vitro studies revealed that the prepared nanocomposites were cytocompatible and only negligible toxicity (less than 10%) induced by CNFs/Fe2O3 fabricated from PAN FeSO4·7H2O 15%. These results showed that the fabricated nanocomposites could be applied as the bone tissue engineering scaffold.


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