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نویسندگان: Hassan Maleki, Maryam Doostan, Masood Khosravani

زمان بندی: بدون زمان بندی

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برچسب: Nanomedicine

کد: GP-02693

خلاصه مقاله: The aim of this work is to co-load paclitaxel (PTX) and etoposide (ETP) in methoxy ‎poly(ethylene....

The aim of this work is to co-load paclitaxel (PTX) and etoposide (ETP) in methoxy ‎poly(ethylene glycol)-poly(lactic-‎co-glycolic acid) nanoparticles (mPEG-PLGA NPs) to ‎overcome the pharmacokinetics and physiological limitations ‎and enhance the therapeutic ‎efficacy for treating intracranial glioblastoma‏.‏‎ Both drugs were loaded into mPEG-PLGA ‎NPs ‎by a nano-precipitation method. PTX/ETP co-loaded mPEG-PLGA NPs had a spherical shape ‎with a mean size of ‎about 150 nm and a high loading efficiency for both PTX (92.5 ± 4.8 %) and ‎ETP (86.2 ± 3.7). The resultant NPs ‎demonstrated an enhanced cytotoxic effect indicated by ‎lower IC50 and augmented cell apoptosis to U87 and C6 ‎glioma cell lines compared to both free ‎drugs. Additionally, blood compatibility assays showed that the PTX/ETP co-‎loaded mPEG-‎PLGA NPs did not induce blood hemolysis, blood clotting, or platelet aggregation. In vivo anti-‎glioma ‎efficacy evaluation in rats bearing intracranial C6 glioma revealed a superior anti-glioma ‎activity for the treatment ‎with PTX/ETP co-loaded mPEG-PLGA NPs compared to other ‎formulations, particularly a significantly longer median ‎survival, 76 day compared to 36 days for ‎free PTX and 37 days for free ETP treatment, respectively, and higher tumor ‎regression approved ‎by magnetic resonance scanning (MRI). ‎


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