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نویسندگان: yazdan choghazardi

زمان بندی: بدون زمان بندی

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برچسب: Nanomedicine

کد: GP-81695

خلاصه مقاله: Radiosensitivity enhancement of targeted bismuth sulfide nanoparticles in radiotherapy of breast....

Radiosensitivity enhancement of targeted bismuth sulfide nanoparticles in radiotherapy of breast cancer Introduction One of the major challenges is related to the non‐targeted nanoparticle which can cause side effects after radiotherapy. Functional ligands such as antibodies, proteins, and peptides bind to the surface of nanoparticles to target specific receptors at the cell surface. This study aimed to assess the radiosensitivity and mechanism of radiosensitivity of Bi2S3@BSA nanoparticles conjugated with triptorelin in breast cancer targeted radiotherapy. Material and method First, nanoparticle characterization was performed, next biocompatibilities of the Bi2S3@BSA and Bi2S3@BSA-Triptorelin NPs on MCF-7 cells were measured by MTT assay. Later, the radiosensitization effects of Bi2S3@BSA-Triptorelin NPs after treatment with 6 MV beams investigate by colony assay Result The average size of the Bi2S3@BSA was 9 nm. MTT test results show the nanoparticles did not cause any toxicity (P˃0.05) Even up to 150 ppm. Colony formation assays showed that the non-toxic concentration of Bi2S3@BSA-Triptorelin significantly increased cell death in MCF-7 cells compared with Bi2S3@BSA (P˃0.05). The apoptosis test also confirmed the results of the colony assay and introduced apoptosis as a mechanism of radiosensitivity produced by nanoparticles. Conclusion Targeting Bi2S3@BSA with triptorelin significantly enhances radiosensitivity and could provide an ideal radiosensitizer for clinical applications in breast cancer targeted radiotherapy. Keywords “Bi2S3 nanoparticles” “Triptorelin” “Targeted Radiotherapy” “Radiosensitizer” “Breast Cancer”


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