بدون زمان بندی
نویسندگان: Fatemeh bahadorani
زمان بندی: بدون زمان بندی
خلاصه مقاله: Abstract: Mesoporous silica nanocarriers are used in new....
Abstract: Mesoporous silica nanocarriers are used in new drug delivery systems because of their special features, including high specific area, good biocompatibility, large pore volume for loading large amount of drug molecules, and easy surface functionalization. In this research, the pH-sensitive, folate-targeted silica mesoporous nanocarriers were synthesized. The FT-IR, XRD, FE-SEM, and Zeta-potential data confirmed the successful synthesis of nanocarriers. Then, the anthrasycline derivative drug was loaded on the synthesized nanocarriers. The optimum amount of drug loaded in 1 mg of the nanocarriers was calculated with comparing, loading capacity and loading efficiency for various ratio of drug to nanocarriers. The in vitro drug release manner was studied by UV-Vis spectroscopy. The results proved that the cumulative drug release inside the tumor acidic pH is more than this amount in a biological environment. Keywords: Mesoporous silica nanocarriers; Targeted drug delivery; pH-sensitive.