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نویسندگان: Elham Dolat, Ameneh Sazgarnia

زمان بندی: بدون زمان بندی

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برچسب: Nanomedicine

کد: GP-64295

خلاصه مقاله: Background: Near-infrared triggered photodynamic therapy (NIR-PDT) has been introduced as a relatively deep tumor....

Background: Near-infrared triggered photodynamic therapy (NIR-PDT) has been introduced as a relatively deep tumor treatment modality. The gold Nanoechinus (Au NE) acts as a transducer to change NIR wavelength to ultraviolet (UV) and visible lights. Au NE converts the irradiation of 980 nm to 674 nm which is absorbed by Zn(II) Phthalocyanine tetrasulfonic acid (ZnPcS). In this study the cooperation effect of Au NE and ZnPcS in PDT on MCF7 and Hela cells was investigated. Methods: Cytotoxicity and phototoxicity of different concentrations of Au NE and ZnPcS upon irradiation of 980 nm NIR light were evaluated against MCF7 and Hela cells after two different incubation times and irradiating with two power densities of laser. Results: In MCF7 cells, which were incubated for 48h with 50 µg/ml Au NE+2µM ZnPcS and were treated by 980 nm laser with a power density of 200 mW cm2 for 15 and 30 min, 48 and 38% cell viability were recorded. No appreciable result was observed due to PDT of Hela cells. Conclusions: NIR-PDT of MCF7 cells, suggested in this study could be a promising modality and carefully increasing the power density and ambient temperature seems to be efficient in the treatment of Hela cells.


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