بدون زمان بندی
نویسندگان: maryam roostaee
زمان بندی: بدون زمان بندی
خلاصه مقاله: This work, a new electrochemical nanosensor based on modified carbon paste electrode (CPE) with Fe3O4@Au-reduced....
This work, a new electrochemical nanosensor based on modified carbon paste electrode (CPE) with Fe3O4@Au-reduced graphene oxide nanocomposite (Fe3O4@Au-rGO) and 1-n butyl-3-methylimidazolium-hexafluorophosphate (ionic liquid (IL)) was fabricated for ultrasensitive determination of doxorubicin (DOX). The Fe3O4@Au-rGO nanocomposite was synthesized by hydrothermal method and characterized by FTIR, UV-Vis, EDS-Mapping analysis, XRD, TEM, FESEM, and VSM. The characteristic evaluation of nanocomposite showed that Fe3O4@Au has a nanometric range, core-shell structure, and successfully immobilized on the surface of graphene oxide. The electrochemical behavior of proposed modified electrode was investigated by cyclic voltammetry (CV), square wave voltammetry (SWV) and chronoamperometry (diffusion coefficient of 22.7×10-5 cm2s-1). The high performance of the modified carbon paste electrode derive from the synergistic effects between Fe3O4@Au and graphene oxide with excellent electrical conductivity. The square wave voltammetric response displayed a linear dynamic range of 0.3‒500 nM and the detection limit of 1.7 nM for DOX. Finally, the measurement of DOX in biological samples such as human plasma and human urine showed a satisfactory results.