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نویسندگان: Huriya Mohammadnejad, Vahideh Nosrati Siahmazgi , Samin Abbaszadeh, Zainab Ahmadian, Bahar Bochani, Mahsa Akbari, Mohammad-Reza Eskandari, Aziz Maleki, Hélder A. Santos, Mohammad-Ali Shahbazi

زمان بندی: بدون زمان بندی

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برچسب: Nanostructure fabrication and characterisation

کد: GP-96571

خلاصه مقاله: The most challenging aspects of cancer therapy include the development of formulations with low/no invasiveness,....

The most challenging aspects of cancer therapy include the development of formulations with low/no invasiveness, minimal toxicity and high selectivity to completely eliminate tumor tissue. At present, radiotherapy and chemotherapy are considered as main approaches for cancer ablation; however, they do not meet needed criteria of desirable formulations. Moreover, inevitable side effects, poor patient’s compliance, and emerging resistance mechanisms have resulted in a remarkable demand for novel revolutionary cancer therapies. Herein, a multimodal pH and near-infrared responsive nanoplatform, which combines the benefits of phototherapy, chemotherapy, and targeting nanosystems is designed. MnO2 coated polydopamine nanoparticles were loaded with sorafenib and further camouflaged within platelet cell membrane to prepare a biocompatible nanohybrid, in which its favourable photothermal performance was combined with the ability of generating reactive oxygen species upon 808 nm near-infrared laser irradiation. The nanohybrid showed a narrow size distribution of smaller than 200 nm and the pH responsivity of MnO2 shell enabled cargo release in the tumor microenvironment.


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